منابع مشابه
Selective glucocorticoid receptor modulators: future of glucocorticoid immunosuppressive therapy?
In 1950 Hench, Kendall, and Reichstein received the Nobel Prize in Medicine for the characterization and isolation of glucocorticoids and the subsequent discovery of their antiinflammatory properties. To date, glucocorticoids are still widelyprescribedandplayanimportantrole inthetreatment of a variety of clinical disorders, including inflammatory diseases, autoimmune disorders, and hematologica...
متن کاملDiscovery of selective glucocorticoid receptor modulators by multiplexed reporter screening.
Glucocorticoids are widely used to suppress inflammation and treat various immune-mediated diseases. Some glucocorticoid receptor (GR)-regulated genes mediate the therapeutic response, whereas others cause debilitating side effects. To discover selective modulators of the GR response, we developed a high-throughput, multiplexed system to monitor regulation of 4 promoters simultaneously. An init...
متن کاملResearch resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.
Glucocorticoid steroids affect almost every type of tissue and thus are widely used to treat a variety of human pathological conditions. However, the severity of numerous side effects limits the frequency and duration of glucocorticoid treatments. Of the numerous approaches to control off-target responses to glucocorticoids, small molecules and pharmaceuticals offer several advantages. Here we ...
متن کاملACTH-dependent regulation of microRNA as endogenous modulators of glucocorticoid receptor expression in the adrenal gland.
MicroRNA (miR) are a subset of small RNA molecules, which posttranscriptionally modulate target gene expression. Although miR have been demonstrated to impact a number of processes during development and tumorigenesis, little is known about the expression and the role of miR in the adrenal gland. Because tight regulation of steroid synthesis is crucial for maintaining homeostasis upon stressful...
متن کاملSelective Estrogen Receptor Modulators
Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target tissue. After tamoxifen, raloxifene, lasofoxifene and bazedoxifene SERMs have been developed and used for treatment. The clinically decisive differ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annales d'Endocrinologie
سال: 2018
ISSN: 0003-4266
DOI: 10.1016/j.ando.2018.03.004